Heavy Metals and Toxicity in the Body

What are the signs or symptoms of heavy metal toxicity? Symptoms of heavy metal toxicity include mental confusion, pain in muscles and joints, headaches, short-term memory loss, gastrointestinal upsets, food intolerances/allergies, vision problems, chronic fatigue, and others. The symptoms are so vague that it is difficult to diagnose based on symptoms alone. Read more

Think You Are Lead-Free? Check Your Soil

(HealthDay News) -- While lead has been phased out of U.S. gasoline, paint and other products, lead levels in dirt -- maybe even the soil in your yard or the local playground -- are still a public health hazard, warns an Indianapolis researcher.

"In urban areas -- Indianapolis, Detroit, St. Louis -- soil lead, even away from the home or the road, is 8 to 10 times higher than natural soil [not exposed to the burden of lead]," noted Gabriel Filippelli, professor of earth sciences and department chair at Indiana University-Purdue University Indianapolis.

He conducted a review of the data on urban soils as a persistent source of lead poisoning, published in a recent issue of the journal Applied Geochemistry. The work was done with lead author, Mark A.S. Laidlaw, formerly a student at the university.

The two also investigated the current "lead burden" in soils from Indianapolis and other cities. Older American cities have a very high lead burden, and it's enough to adversely affect children's health, Filippelli contended.

It's especially bad when the wind kicks up in dry temperatures and spreads the lead-laden soil around. "That is when kids' blood levels go up," the expert said.

While blood levels during these windy times have not been shown to typically rise past what's considered a healthy limit by federal guidelines, Filippelli said, many studies have shown that ill health effects can kick in below that established level.

According to Filippelli and other experts, a child's developing digestive system is especially susceptible to lead poisoning. At the atomic level, lead looks similar to calcium, he said, since the two substances are similar in size and ionic charge. That means the body's nervous system can readily take up lead instead of calcium, potentially leading to neural deficits.

Solutions? Municipalities have to try aggressively to control the lead-laden soil, Filippelli said. Spraying the dirt with water using high-powered shower systems is one way to decrease the lead content and minimize lead poisoning. But this must be done regionally, since doing one house but not the one next door won't solve the problem, he added.

Another remedy, much more costly and probably less feasible, is to put a layer of clean soil on top of the contaminated soil and then grass seed, Filippelli said.

And what can the average consumer do? "Water your yard regularly," the expert said, unless you live in an area with water rationing or restrictions. Meanwhile, Filippelli is continuing research to convince municipalities that efforts spent on getting rid of lead in soil is money well spent.

Getting the Lead Out

The finding that lead is prevalent in soils, especially in urban areas, is no news to Ruth Ann Norton, executive director of the Coalition to End Childhood Lead Poisoning, based in Baltimore.

"Urban soil is an important source of lead," she said. But she added that housing still tops the list for lead exposure due to old lead-based paints. Numerous products that used lead as a stabilizer, such as furniture, old mini-blinds, old paint and old costume jewelry, may still be in people's homes, she added.

Some tips on avoiding or removing lead:

• Repair chipping paint, especially old paint. "If you live in an older home (pre-1978), and you have chipping peeling or flaking, you want to repair that safely," she said. That means not dry scraping but wet scraping -- and probably getting professional advice if you decide to do it yourself.
• Know that a little lead can go a long way. "A lead chip the size of a nickel, if broken down, could contaminate a 3,000-square-foot house," Norton said.
• Minimize exposure, especially if you live in an older neighborhood that's likely to have lead in the soil. "Leave your shoes at the door," she said. "Have a welcome mat you can wash off."

More information
Find out more about lead poisoning at the U.S. Environmental Protection Agency.

Heavy Metal Detoxification For Your Autistic Child

Autism is a neurological brain disorder. It is often evident when a child does not hit his or her developmental milestones by age of three. The symptoms observered include a delay in speech, unable to interact socially and behavioral disturbances.

Some experts say that autism may be caused by a exposure. Mercury is known to cause neurological disorders as it mainly triggers brain dysfunction. Mercury is likely to be absorbed by the body if it is presented as ethyl mercury that are usually used in thimerosal, preservatives, and additives and even in pediatric vaccines.

Hence to get rid of the mercury, it appears that it is necessary to do a heavy metal detox or a mercury detox. Heavy metal detox is a process where chelating agents aid the body into excreting heavy metals by bonding with the toxic materials and make them less active. Heavy metal detox is in progress when hazardous metals are absorbed by the bloodstream and is excreted safely by the liver or kidney. Continue Reading >>

What Toxic Chemicals & Heavy Metals Affect My Health?

For your benefit and education, we have included the lists below covering the more common toxic heavy metals and chemicals. This page is still under construction and soon we will be uploading detailed descriptions of each of the substances listed below, their related health hazards and sources of exposure.

Common Toxic Metals:

• Arsenic
• Aluminum
• Barium
• Beryllium
• Bismuth
• Cadmium
• Chromium Hexavalent
• Cobalt
• Copper
• Lead
• Mercury
• Nickel
• Tin
• Titanium
• Uranium

Common Toxic Chemicals:

• Antimony
• Asbestos
• Aspartame
• Acesulfame-K
• Acetone Peroxide
• Acrylamide
• Benzene
• Bisphenols
• Chlorine
• DDT
• Dioxins
• Flouride
• Formaldehyde
• HCA's
• Insecticides
• Isopropyl Alcohol
• MSG
• Methyl alcohol
• Pesticides
• Persistant Organic Pollutants
• rBGH
• Nitrates
• Prescription Drugs
• Synthetic Vitamins
• Sodium Chloride
• Refined sugar
• High Fructose Corn Syrup
• Sucralose
• Saccharin
• VOC's
• Carbon Monoxide
• Chlorofluorocarbons
• Perchloroethelyne
• Propane
• Radon
• Toluene
• Phthalates
• Xylene
• n-hexane
• ethyl ketone
• Phenol
• Ammonia
• Sodium Hydroxide
• Carbaryl
• Dichlorophene
• Chlordane

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Chelation Therapy

Here is occlusive coronary atherosclerosis. The coronary at the left is narrowed by 60 to 70%. The coronary at the right is even worse with evidence for previous thrombosis with organization of the thrombus and recanalization such that there are three small lumens remaining.

Atherosclerosis, or "hardening of the arteries", is the cause of two most deadly health problems Unfortunately, it begins quite early in life and continues relentlessly until circulation is so compromised that a heart attack or a stroke is almost certain. The process begins innocently enough, by formation of a small plaque on the wall of an artery. It attracts platelets that form a small blood clot. Later on, additional clotting elements increase the size of the clot. Eventually cholesterol and calcium get deposited into the growing plaque. Calcium completes this process, making the arteries "hard".

This is a normal coronary artery with no atherosclerosis and a wide lumen that can carry as much blood as the myocardium requires. Normally arteries have the ability to expand or contract, depending on the need of the body. But once the calcium is settled on the arterial walls, they become rigid, unable to either expand or contract. That’s where the expression "hardening of the arteries" comes from. The cells of the body require continuous blood supply in order to live. When it stops, most cells die within a few minutes. If this happens in the heart, the result is known as a heart attack. In the brain, it is called a stroke.

MAJOR SYMPTOMS Chest pain (angina) because of decreased circulation within the heart, memory loss, dizziness, poor balance from reduced blood flow to the brain, pain in the legs after walking which is relieved by rest.

TRADITIONAL – TREATMENT Hardening of the arteries is a systemic disease. In other words, it happens throughout the body, not just in one or 2 areas. If you understand this, you will realize that the current approach to treatment is crude, primitive and misguided. Some experts have compared it to putting a band-aid on a major injury.

When a surgeon performs a bypass surgery or an angioplasty, it does nothing to correct the widespread atherosclerosis already present in other parts of the body, such as brain, kidneys, lungs, legs and everywhere else. To complicate matters further, most of the arteries are very small. They are called capillaries, and they comprise the majority of the 40 to 60 thousand miles or arteries feeding the tissues of the body.

The diameter of a capillary is smaller than the size of a red blood cell. This is necessary for the exchange of oxygen and nutrients to take place. Obviously, these arteries can not be bypassed or surgically manipulated. Various medications used for "treatment" of heart disease are designed to deal only with the symptoms, not the real causes of the problem. Clearly, the real treatment for atherosclerosis would be a procedure that removes the plaques from the arteries and restores blood flow all over the body, in large arteries as well as small ones. And this brings us to

CHELATION – THERAPY
Chelation Therapy is probably one of the most effective treatments for hardening of the arteries, yet it is being ignored and even maligned by mainstream medicine. Chelation therapy was used successfully in over 1 million clients over the last 40 plus years. The main ingredient of chelation therapy is a synthetic amino acid known as EDTA (ethylene-diamine-tetra-acetic acid). It has a peculiar ability to strongly attract minerals, especially toxic metals - lead, mercury, cadmium, aluminum and others. Since then, a number of studies published in reputable medical journals have confirmed the effectiveness of IV chelation therapy for treating atherosclerosis and improving blood flow to the heart, the legs and the brain.

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Top 20 Reasons Why You Need A Chemical & Heavy Metals Cleanse:

Top 20 Reasons Why You Need A Chemical & Heavy Metals Cleanse:

1 - One out of every ten women of childbearing age has dangerously high concentrations of mercury "…within one tenth of potentially hazardous levels" in their bloodstream.1
2 - Many people have developed colitis from chronic ingestion of mercury-containing laxatives.
3 - Industrial contaminants (such as dioxins, PCBs, and mercury), microbial contaminants (such as E. coli), and natural contaminants (such as aflatoxin) [can be found in foods]."2
4 - "In 1994, 62% of all food samples tested by the U.S. Department of Agriculture's Pesticide Data Program (PDP) had detectable levels of at least one pesticide."3
5 - "PDP data from 1994-96 … [stated 25] percent of the food samples tested had detectable levels of carcinogenic (cancer causing) pesticides, and 34%" possessed detectable levels of neurotoxic pesticides.4
6 - Some studies estimate 99% of the breastmilk in women residing in the United States contains measurable levels of DDT (Dichloro-Diphenyl-Trichloroethane), the first modern toxic chemical pesticide.
7 - In the United States, eight times more antibiotics are used for the livestock industry than for human inoculation against disease.5
8 - In a study where pigs were fed large amounts of synthetic B vitamins, the pigs produced sterile offspring. Synthetic vitamins provide no nutritional value-they are poisonous!
9 - Chlorine, acetone peroxide, benzoyl peroxide, and nitrogen dioxide are the most common oxidizing agents used during white flour processing in the production of white bread.
10 - The Center for Science in the Public Interest, a nutritional lobbying group, claims that sodium chloride (common table salt) could be "… the single deadliest ingredient in the food supply."6
11 - MSG is a toxic substance and causes adverse reactions, brain lesions, endocrine disorders, and other negative health problems."7
12 - "The chemical, acrylamide, which is used industrially in the manufacturing of some plastics, is also apparently formed by the heating of starches. Foods with especially high levels of the chemical included French fries, potato chips and crackers."8
13 - An alarming study published in the American Journal of Public Health estimates a 95% risk of developing cancer from regular consumption of chlorinated tap water!9
14 - After being inside the body for 20 minutes, Aspartame begins breaking down from its original compound into methanol, formaldehyde (a Class-A carcinogen used to embalm corpses) and formic acid (ant venom).
15 - Over 70% of the world's coffee supply is contaminated with toxic pesticides and chemicals. It's estimated that just one cup of coffee contains more than 2,000 chemicals, many of which are gastrointestinal irritants and cancer-causing agents. Also, the high heat used in roasting coffee beans causes the natural oils to turn rancid, further contributing to its chemical load.
16 - Playing and crawling on a typical floor exposes babies to contaminants such as dust mites, mold and mildew. Just one day of exposure introduces the equivalent of four cigarettes into an infant's lungs.10
17 - "Every year, indoor air pollution is responsible for the death of 1.6 million people - that's one death every 20 seconds…due to pneumonia, chronic respiratory disease and lung cancer…"11
18 - The EPA lists over eighty "regulated" contaminants found in tap water such as chlorine, fluoride, arsenic, and numerous pesticides. This figure doesn't even include unregulated toxins such as perchlorate (a chemical found in rocket fuel!).
19 - The National Resources Defense Council (NRDC) estimates "…as many as 56 million people in the 25 states reviewed by the U. S. Environmental Protection Agency … have been drinking water with unsafe levels of arsenic..."! 12 Arsenic is the number 1 cancer causing agent!
20 - Bottled water, infant formulas, toothpaste, mouthwash and even vitamin supplements, now contain fluoride! Fluorides are more toxic than lead and only slightly less poisonous than arsenic.

Resources:
1 Centers for Disease Control and Prevention. "Blood and Hair Mercury Levels in Young Children and Women of Childbearing Age - United States, 1999." Morbidity and Mortality Weekly Report. Vol. 50, Issue 8. (140-3). Pub. 2 March 2001. Online. Accessed 17 Aug 2007. Available: www.cdc.gov/mmwr/preview/mmwrhtml/mm5008a2.htm

2 United States Environmental Protection Agency. "America's Children and the Environment: A First View of Available Measures." Document # EPA 240-R-00-006. Pub. Dec 2000. Pp. (32-3). Online. Accessed 30 July 2007. Available as PDF: www.yosemite.epa.gov/ochp/ochpweb.nsf/content/ACE-Report.htm/$file/ACE-Report.pdf

3 United States Environmental Protection Agency. "America's Children and the Environment: A First View of Available Measures." Document # EPA 240-R-00-006. Pub. Dec 2000. Pp. (32-3). Online. Accessed 30 July 2007. Available as PDF: www.yosemite.epa.gov/ochp/ochpweb.nsf/content/ACE-Report.htm/$file/ACE-Report.pdf

4 United States Environmental Protection Agency. "America's Children and the Environment: A First View of Available Measures." Document # EPA 240-R-00-006. Pub. Dec 2000. Pp. (32-3). Online. Accessed 30 July 2007. Available as PDF: www.yosemite.epa.gov/ochp/ochpweb.nsf/content/ACE-Report.htm/$file/ACE-Report.pdf

5 Epstien, S. "Potential public health hazards of biosynthetic milk hormones." International journal of health services : planning, administration, evaluation. Vol. 20, Issue 1. (73-84). Online. Accessed 8 Nov 2007. Available: www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed
(PMID=2407676)

6 Michael F. Jacobson, Ph.D. "Press Conference on Salt: the Forgotten Killer." Pub. 24 Feb 2005. Online. Accessed 6 Aug 2007. Available as PDF: www.cspinet.org/new/pdf/final_mj_salt_statement.pdf

7 Truthinlabeling.org "Where is MSG hidden?" Online. Accessed 7 Aug 2007. Available: www.truthinlabeling.org/II.WhereIsMSG.html

8 Kaufman, Marc. "WHO to Talk About Food Carcinogen Finding." The Washington Post. Pub. 27 Apr 2002. Online. Accessed 7 Aug 2007. Available: (Contact Washington Post Archives).

9 Morris, R., Audet, A., Angelillo, I., Chalmers, T. and F. Mosteller. "Chlorination, Chlorination By-products, and Cancer: A Meta-analysis." American Journal of Public Health. Pub. July 1992. Vol. 82, Issue 7. Online. Accessed 14 Aug 2007. Available as PDF: www.ajph.org/cgi/reprint/82/7/955

10 World Health Organization. "Indoor air pollution and health." Online. Accessed 10 Aug 2007. Available: www.who.int/mediacentre/factsheets/fs292/en/index.html

11 World Health Organization. "Indoor air pollution and health." Online. Accessed 10 Aug 2007. Available: www.who.int/mediacentre/factsheets/fs292/en/index.html

12 Natural Resources Defense Council. "Arsenic in Drinking Water." Online. Accessed 14 Aug 2007. Available: www.nrdc.org/water/drinking/qarsenic.asp

Chemical & Heavy Metal Cleanse Starter Kit $149.85 [ learn more ] The Chemical & Heavy Metal Starter Kit was designed by Dr. Group for individuals that are new to the cleansing process, or are simply looking for an easy-to-perform, cost effective cleanse program. The Heavy Metal Starter Kit is comprised of LIFE Detox Foot Patches™, NDF Plus™, and Quantum Zeolite™.

Dr. Morton Walker Speaks on Detoxamin

Environmentalists warn us repeatedly that we live on a poisoned planet. Toxins from mercury, lead, aluminum, cadmium, iron, nickel, and about 20 more metallic minerals permeate the Earth's milieu. Heavy and light metals poison us by combining to create deleterious signs and symptoms often referred to collectively as Toxic Metal Syndrome.

This syndrome, an indicator of serious systemic pathology, results in degenerative diseases which affect no less than 92% of the populations of Western industrialized nations, in particular, those people living in apartment high-rises and other polluted city dwellings.

What happens to them?

These poisoned people eventually come down with manifestations of degenerative illnesses such as heart and/or blood vessel deteriorations; pancreatitis; gout, rheumatoid arthritis or osteoarthritis; the syndromes of yeast, chronic fatigue, and/or irritable bowel; Alzheimer's disease, multiple sclerosis, parkinsonism, cancer and many more.

Although a poisoned person's bones remain toxic for life, excellent self-treatment exists to reduce or reverse most symptoms of illness in other body parts. First, get tested for the extent of toxicity, then neutralize metallic poisoning with a chelating agent such as Detoxamin.

By applying the highly efficacious Detoxamin suppository containing Ca-EDTA, you remove toxic metal from cells all over the body. The self-administration is performed rectally before retiring so that as you sleep you remove the toxins. There's no more need for intravenous infusions.

Rectal chelation therapy does the job of detoxifying in a low-cost, convenient manner; it's an effective way to effuse EDTA through the bowel's walls and into your blood stream to clean toxic metals from all body cells.

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Chemical & Heavy Metal Cleanse Starter Kit $149.85 [ learn more ] The Chemical & Heavy Metal Starter Kit was designed by Dr. Group for individuals that are new to the cleansing process, or are simply looking for an easy-to-perform, cost effective cleanse program. The Heavy Metal Starter Kit is comprised of LIFE Detox Foot Patches™, NDF Plus™, and Quantum Zeolite™.

Aluminum

Aluminum toxicity is a serious condition that occurs when a person absorbs excessive amounts of aluminum—a metal that often deposits itself in the brain. Aluminum is the most abundant metallic element in the earth’s crust and is introduced into the body through the digestive system, lungs and skin, before it is absorbed into the tissues.

The highest exposure to aluminum is most frequently due to chronic consumption of aluminum-containing antacid products. Research shows that aluminum builds up in the body over time, creating an increased health hazard as people get older.

Aluminum toxicity can lead to symptoms similar to Alzheimer’s disease and osteoporosis and can impair kidney function. Aluminum toxicity can also lead to colic, rickets, gastrointestinal problems, poor calcium metabolism, anemia, headaches and decreased liver function. A disturbing pattern of aluminum accumulation and interference with normal neurological function appears to be supported in many scientific arenas.

Recent studies suggest that aluminum contributes to neurological disorders such as Alzheimer’s disease, Parkinson’s disease, senile and pre-senile dementia, clumsiness of movements, staggering when walking, and the inability to pronounce words properly. Autopsies, performed on people who have died of Alzheimer’s disease, showed accumulations of up to four times the normal amount of aluminum in the nerve cells of the brain. Levels were especially high in the hippocampus, which plays a central role in memory.

There are also geographical links between Alzheimer’s disease and high aluminum in drinking water. Elevated hair aluminum has been observed in Alzheimer’s patients. Amyotrophic lateral sclerosis, another neurodegenerative disease, may also be linked to aluminum content of water supplies. Behavioral difficulties among schoolchildren have also been associated with elevated levels of aluminum and other neurotoxic heavy metals. Studies show that dyslexic children have higher levels of aluminum in their hair, when compared with controls.

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Cadmium

Cadmium is a widespread heavy metal in the environment and in our bodies. It is very poisonous, and we only excrete cadmium in very small amounts.

Cadmium can cause damage to all types of body cells. By damaging the cell membrane, cadmium increases the permeability of the cells, one of the consequences being that the transfer of other heavy metals into the cells is facilitated. In the acute stage, cadmium intoxication causes enteritis. A slow accumulation of cadmium takes place, mainly in the kidneys; the liver and bones are other important sites for cadmium storage.

Food products account for more than 90 percent of human exposure to cadmium, except in the vicinity of cadmium-emitting industries, according to the Agency for Toxic Substances and Disease Registry. Cadmium has fast uptake through the roots to edible leaves, fruits and seeds. Cadmium builds up in animal milk and fatty tissues. A 1990 study showed that acute cadmium toxicity from food is rare, but chronic exposure at lower levels increases cadmium in certain body organs.

One source of cadmium in our environment, and main reason for cadmium accumulating in the body, is tobacco smoke. One cigarette contains 16-24 mcg. of cadmium of which the body absorbs approximately half. In addition to this, 5 - 10% of the cadmium from our food and other sources is absorbed; therefore, a substantial amount of cadmium is stored in our body system over a number of years.

Prolonged accumulation of cadmium in the body stains the teeth. It can cause damage to the nervous system, decrease the detoxification power of the organism, it can cause high blood pressure and atherosclerosis, damage the immune system; most importantly the antibody production, decrease fertility, cause anemia, emphysema, and cancer.

Increased concentrations of cadmium had been found in the placenta of women who have given birth to children with low birth weight, neural damage, and Down’s syndrome. Children who are exposed to large concentrations of cadmium in their environment often have learning disabilities.

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Toxic Heavy Metals

We have been exposed to heavy metal toxins for an immeasurable amount of time. The industrialization of our planet has drastically increased the environmental burden of heavy metal toxins, to the point that we are dependent upon them for proper functioning.

Industry and commercial processes are actively mining, refining, manufacturing, burning, and manipulating heavy metal compounds for many reasons. Presently, heavy metals are abundant in our drinking water, air and soil due to our increased use of these compounds. They are present in virtually every area of modern consumerism.

Toxic metals are found in construction materials, cosmetics, medicines, processed foods, fuel sources, appliances, personal care products and so much more. It is very difficult, if not impossible, for anyone to avoid exposure to any of the many harmful toxic heavy metals that are so ubiquitous in our environment. It doesn’t look like we will successfully neutralize the threat of heavy metal toxicity in our communities, nor diminish our use of the many commercial goods that they help produce. We can, however, take steps to understand and deal with this threat. Cadmium, aluminum, mercury, antimony, lead and arsenic are some of the heavy metals added to our food chain from upstream industrial discharges, pesticide runoff, incinerator emissions, and smokestacks, as well as aviation.

Heavy metals are found in the air we breathe, from factories, automobiles and in places you wouldn’t imagine. Low-level metal toxicity is recognized by the Environmental Protection Agency (EPA), the Food & Drug Administration (FDA), and the Centers for Disease Control (CDC), as well as by individual state health departments.

The American Heart Association states that blood-levels of lead and cadmium may increase the risk of peripheral artery disease — even at levels currently considered safe. Low-level toxicity from heavy metals and the resulting “oxidative stress” are associated with a depressed immune system, increases in infertility, cancer, cardiovascular disease, and premature mortality.

Emerging evidence shows that blood and bone lead levels, reflecting relatively modest exposures, are also associated with hypertension, renal insufficiency, and cognitive impairment. Studies conducted at the National Academy of Science (NAS) show clear and present danger of heavy metals in our bodies. Tuna, dental fillings and vaccinations containing mercury, can cause problems including birth defects, brain damage, depression, fatigue, hearing loss, vision loss, kidney damage and many more ailments.

The really bad news is that, according to the EPA, 99% of our population contains chemicals that are linked to the development of cancer. Most heavy metals are carcinogenic and can cause free radical damage. They can cause the energy factories in our cells (known as mitochondria) to stop working, which essentially causes cells to die. In the process, the DNA for those affected cells may also be damaged, causing a malfunction in the next generation of cells of this type.

When cells are programmed to die off more quickly or to wildly multiply, we see problems such as weaker tissue, maligned function, or tumors. In short, heavy metals lead to serious illnesses and shorten our lives. There are more than twenty different heavy-metal (environmental) toxins that can impact human health—each toxin producing unique behavioral, physiological, and cognitive changes in an exposed individual.

The degree to which a system, organ, tissue, or cell is affected by a heavy metal toxin depends on the toxin itself and the degree of the individual’s exposure. Here we examine just five of the many hazardous heavy metals that we are commonly exposed to.

Chemical & Heavy Metal Cleanse Starter Kit $149.85 [ learn more ] The Chemical & Heavy Metal Starter Kit was designed by Dr. Group for individuals that are new to the cleansing process, or are simply looking for an easy-to-perform, cost effective cleanse program. The Heavy Metal Starter Kit is comprised of LIFE Detox Foot Patches™, NDF Plus™, and Quantum Zeolite™.

An End to Prostate Problems?

Breakthrough Detoxification Research Now Being Conducted

California, August 30, 2006. Prostate conditions such as prostatitis, enlarged prostate and prostate cancer are affecting men worldwide. In fact, more than 50% of all men 50 and over suffer from an enlarged prostate (Benign Prostate Hyperplasia or BPH).

The problem gets worse as men age. That’s just one possible prostate condition. Another widespread affliction is prostatitis. It affects younger as well as older men. This week, World Health Products received full Investigational Review Board (IRB) approval to conduct clinical trial on an innovative detoxifying product, Detoxamin®, in conjunction with the antibiotic, tetracycline. Pre-study trials indicate that this combination therapy will reduce or eliminate prostate problems.

The study is slated to begin September 9, 2006 at the Tustin Longevity Center in Tustin, California under the direction of Rita Ellithorpe, MD, a specialist in integrative medicine.

A recent discovery has revealed a minute life form, much smaller than the smallest bacteria. It’s called nanobacteria. Many medical scientists believe these culprits cause hardening of the arteries, kidney stones and other degenerative conditions. These ultra microbes are thought to encase themselves in a shell of calcium.

Researchers involved in this current study have uncovered convincing evidence pointing to nanobacteria forming calcifications or stones on the prostate. These continually growing stones are thought to cause pressure on the prostate giving rise to prostatitis and BPH. Studies suggest that calcium biofilm surrounding the nanobacteria can removed by an amino acid, EDTA, contained in a product called Detoxamin.

The nanobacteria are exposed and then destroyed by tetracycline. This one-two approach of killing the nanobacteria with tetracycline and dissolving the calcium deposits with Detoxamin is the foundation for conducting this study. There is evidence that EDTA also has beneficial results in diminishing hardening of the arteries, atherosclosis. Detoxamin also chelates or binds poisonous heavy metals within deep tissues and enables the body to easily eliminate the toxins through urine and feces. “Our clinical trial will determine if prostate calcifications will either reduce in size or be eliminated altogether.

Furthermore, we will also find out if symptoms decrease or disappear,” says Larry Clapp, PhD, co-investigator and author of Prostate Health in 90 Days.
Toxic heavy metals have been implicated in many diseases of aging from Alzheimer’s, to cardiovascular disease. “I have over 500 patients with a variety of conditions in my practice that I placed on Detoxamin; the reason, because mostly everyone I have tested has a variety of heavy metal build up in their bodies.

Detoxamin is a safe, effective and convenient way to remove these menacing toxins. Therefore, we eliminate the causative agents so that other therapies can work in combination and repair the damage heavy metals cause to cells, tissues and organs,” as stated by Dr. Ellithorpe, the Principle Investigator of the study. This new clinical study supports the use of combination therapy to curtail or eliminate the growing prostate problems.

more information at: Chelation

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Detoxamin EDTA Chelation Therapy Suppositories are a new patented method of Ca-EDTA chelation therapy medically equivalent to I.V. chelation therapy.

Detoxamin EDTA Chelation Therapy Suppositories are a new patented method of Ca-EDTA chelation therapy medically equivalent to I.V. chelation therapy.

The difference is that Detoxamin introduces a smaller dosage of Calcium Disodium EDTA on a nightly basis.

By applying the highly efficacious Detoxamin suppository containing EDTA, you remove toxic metal from cells all over the body.

The self-administration is performed rectally before retiring so that as you sleep you are taking chelation therapy with EDTA. There's no need for intravenous infusions or quantities of nutritional supplements.

What is EDTA chelation therapy and what is it used for?Chelation (pronounced key-lay-shun) is the process by which a metal or mineral (such as lead, mercury, iron, arsenic, aluminum, etc.) is bonded to another substance-in this case an amino acid called EDTA, Ethylene-Diamine-Tetra-Acetic acid. It is a natural process, basic to life itself. During EDTA chelation therapy, the EDTA infusion bonds with unwanted metals in the body and quickly carries them away in the urine.

Chelation therapy is a safe, effective alternative to drugs and surgeries and is used to treat many illnesses now known to be linked to the presence of toxic heavy metals. Illnesses such as heart disease, strokes, diabetes, circulatory disorders, neuropathies, Alzheimer's disease, atherosclerosis, and adverse reactions to many environmental pollutants. Traditional chelation therapy uses an intravenous drip, and is administered in the outpatient setting.

The number of treatments vary based on each person's individual condition and/or goals of treatment. The average therapy is given one to three times a week for twenty to thirty treatments.How long has EDTA chelation therapy been in use? Why don't more people use it?EDTA chelation therapy for the detoxification for heavy metals has been in continuous use since the 1940s when it was introduced specifically for the treatment of lead poisoning. It was very quickly observed that as the metals were eliminated, not only did the signs and symptoms of lead poisoning abate, but problems related to the circulatory system like heart attacks, angina, strokes, and peripheral vascular disease also improved.

For the past 50 years, well over one million people have received the intravenous form of EDTA chelation. As beneficial and life saving as this therapy has become, it is very expensive and very time-consuming, making it out of reach for most people.Why is Ca-EDTA, Calcium Disodium EDTA, so much better than other types of chelation therapy?According to Dr. Bruce Halstead, "The chemistry of all chelators is such that a change of pH can dramatically effect the process of chemical binding needed to chelate a mineral or metal. When you use a less effective chelator, such as Magnesium EDTA, you lose all chelating ability of the two most essential heavy metals: lead and mercury. Magnesium di-Potassium EDTA has a dramatically lower chelating effectiveness than Calcium EDTA because both magnesium and potassium dramatically decrease the pH in the blood environment to which it is introduced. Any factor decreasing pH renders EDTA less effective.

Once the pH is lowered more than 7.38, it's no longer chemically conducive to any bonding or chelating." (Dr. Halstead is well known as the 'Father of Chelation Therapy'.)

Dr. Morton Walker Speaks on Detoxamin - Toxic Metals Induce Degenerative Diseases; Rectal Chelation Therapy Overcomes Them.

Environmentalists warn us repeatedly that we live on a poisoned planet. Toxins from mercury, lead, aluminum, cadmium, iron, nickel, and about 20 more metallic minerals permeate the Earth's milieu. Heavy and light metals poison us by combining to create deleterious signs and symptoms often referred to collectively as Toxic Metal Syndrome.

This syndrome, an indicator of serious systemic pathology, results in degenerative diseases which affect no less than 92% of the populations of Western industrialized nations, in particular, those people living in apartment high-rises and other polluted city dwellings. What happens to them? These poisoned people eventually come down with manifestations of degenerative illnesses such as heart and/or blood vessel deteriorations; pancreatitis; gout, rheumatoid arthritis or osteoarthritis; the syndromes of yeast, chronic fatigue, and/or irritable bowel; Alzheimer's disease, multiple sclerosis, parkinsonism, and many more which may be deadly-cancer for instance.

Although a poisoned person's bones remain toxic for life, excellent self-treatment exists to reduce or reverse most symptoms of illness in other body parts. First, get tested for the extent of toxicity, then neutralize metallic poisoning with a chelating agent such as Detoxamin. By applying the highly efficacious Detoxamin suppository containing EDTA, you remove toxic metal from cells all over the body. The self-administration is performed rectally before retiring so that as you sleep you are taking chelation therapy with EDTA. There's no need for intravenous infusions or quantities of nutritional supplements.Rectal chelation therapy does the job of detoxifying in a low-cost, convenient manner; it's an effective way to effuse EDTA through the bowel's walls and into your blood stream to clean toxic metals from all body cells.

Do I need Ca-EDTA chelation therapy?
We find ourselves existing in a far more toxic and hostile environment than our bodies were designed to handle. Experts have shown that almost every health problem-from learning disorders to cancer and heart disease-is aggravated by the approximate 1,000% increase in lead levels in our bones. In 1999, it was reliably reported that hearts with some form of disease have 20,000 times more toxic heavy metals than healthy hearts."Human exposure to heavy metals has risen dramatically in the last 50 years as a result of an exponential increase in the use of heavy metals in industrial processes and products." says Maile Pouls, Ph.D (Townsend Letter for Doctors and Patients, July 1999).A recently concluded "Body Burden" study by New York's Mt. Sinai Hospital and the Environmental Working Group was reviewed by University of Oregon Professor Joseph Thornton: "It shows the universality of chemical contamination of people's bodies," Thornton said.

All the studies "confirm the general message that everybody in our society has these chemicals building up. Some people have it worse than others, but everyone has it. No one is clean anymore." (From Being Careful Can't Keep Chemicals Out of Your Body, Miami Herald, February 1, 2003.)Today we know that about one out of every 2.5 Americans will get cancer. Ninety eight percent of cancer is caused by toxic chemicals. When 50% of all men and 33% of all women living now will die of cancer, something is terribly wrong. (Mortality from cancer was reduced by 90% during an 18-year study of 59 patients treated with Calcium-EDTA. This and over 40 other studies prove the efficacy of Ca-EDTA, Calcium Disodium EDTA chelation therapy and Detoxamin. We will all function better and live longer if we lower the overall burden of toxic metals within ourselves. If you eat or breathe, you will probably benefit greatly from chelation therapy.

Is Detoxamin safe for children?
Yes. In fact, Detoxamin case studies were conducted on lead poisoning in children. The study showed no significant increase in BUN or creatinine levels even in very young children. Due to our lower dosage and time release formulation, no renal toxicity was encountered.BEHAVIORAL, STRUCTURAL, FUNCTIONAL ABNORMALITIES ASSOCIATED WITH VARIOUS HEAVY METAL TOXINS.Reference: Published in the August issue of Alternative & Complimentary Therapies (a magazine for doctors) and Published in Townsend Letter for Doctor's and PatientsPsychiatric Disturbances:
Social Deficits, Social withdrawal

Mercury
Repetitive, perseverative, stereotyped behaviors; OCD-typical behaviors
Mercury
Depression, mood swings, flat affect; impaired facial recognition

Arsenic, Copper, Lead, Mercury
Schizoid tendencies; hallucinations; delirium
Mercury
Irritability, aggressive behaviors, temper tantrums
Lead, MercurySuicidal Behaviors
Copper, MercurySleep difficulties / disturbancesLead, Mercury, Thallium
Chronic fatigue (CFS); weakness, malaise
Aluminum, Arsenic, Cadmium, Copper, Lead, Mercury, Thallium
Anorexia; symptoms reflecting eating disorders, loss of appetite/weight
Arsenic, Lead, Mercury
Anxiety; nervous tendencies

Thallium
Attentional problems (ADHD), lacks eye contact, impaired visual fixation
Lead, Mercury

Speech and Language Deficits: Speech disorders
A luminum, MercuryLoss of speech, developmental problems with language Mercury
Speech comprehension deficits

Mercury
Dysarthria; articulation problems; slurred speech, unintelligible speech
Mercury
Cognitive Impairments:Mental retardation, borderline intelligence

Arsenic, Lead, Mercury
Uneven performance on IQ scores, low IQ scores
Copper, LeadPoor concentration, attention deficits (ADHD, response inhibition

Aluminum, Lead
Poor memory (short term, verbal, and auditory)
Aluminum, Lead

Difficulties understanding abstract ideas; difficulty carrying out complex commands

X metals
Dementia; pre-senile and senile dementia
Aluminum
Stupor

Aluminum, Arsenic

Impaired reaction time; lower performance on timed tests

Lead
Sensory Abnormalities:
Abnormal Sensations in the mouth and extremities
Arsenic
Hearing loss, difficulty hearing
Arsenic, Lead, MercuryAbnormal touch sensations; diminished touch sensations, aversion to touch
Arsenic
Blurred vision; sensitivity to light
Arsenic, Mercury
Motor Disorders:
Choreiform movements, myoclonal jerks, unusualpostures

Copper, Mercury
Difficulty walking, swallowing, talking
Copper, Mercury

Flapping, circling, rocking, toe walking
Mercury
Problems with intentional movements or imitation
MercuryAbnormal, gait/posture; incoordination, loss of balance; problems sitting, lying, crawling and walking
Mercury

Decreased locomotor activity
Aluminum, Arsenic
Convulsion; seizure
Aluminum, Arsenic, Copper, Lead, Mercury, Thallium

Physiological Impairment, Brain and Central Nervous System:
Neurofibrillary tangles
Aluminum
Neuritis, retrobulbar neuritis; neuropathy
Aluminum, Arsenic, Lead, Thallium
EncephalopathyAluminum, Arsenic, Lead, Thallium
Cerebrovascular diseaseX metals

Alterations in nerve conduction velocity
Lead
Alterations in the spinal cordThalliumAccumulates in CNS structures
Aluminum, MercuryAbnormal EEGs

Arsenic, Lead
Autonomic disturbancesCopper, Lead, Mercury, Thallium

Peripheral Nervous System:Peripheral neuropathyArsenic, Mercury

Alterations in peripheral nerves
Arsenic
Loss of feeling/ numbness in the extremities; paresthesia

Arsenic, Mercury, Thallium

Gastrointestinal Tract:
Nausea, vomiting, diarrhea; loss of appetite

Arsenic, Mercury

Abdominal pain, stomach cramps; burning of the throat of the mouth

Arsenic, Copper, Lead, Mercury, Thallium

Esophagitis; gastroenteritis; colitis

Arsenic, Mercury, Thallium Cancers (colon, pancreatic, stomach, or rectal) Arsenic

Renal and Hepatic Impairment:Hepatotoxicity; Liver dysfunction, damageArsenic, Copper, Thallium

Cirrhosis of the liver; hepatitis

Copper

Kidney disease; kidney failureArsenic, Lead, MercuryRenal toxicity; tubular proteinosisArsenic, Copper, LeadKidney Damage, histological alterations

Arsenic, Lead
Cardiovascular System:Blood vessel damage

ArsenicAnemia; decreased red blood cell count

Arsenic, CopperHypertension; increased heart rate (tachycardia)

Arsenic, Copper, Lead, Thallium

Electrocardiac disorders, Peripheral vascular disease; cardiovascular disease, vascular collapse

Arsenic, Lead
Respiratory System:Pulmonary Fibrosis

Aluminum, Arsenic
Pulmonary edema

X metals
Pneumonia, laryngitis, pharyngitis, bronchitis

Aluminum, Arsenic, Mercury
Restrictive airway disorders, asthmatic conditions, pneumoconiosisArsenic, Aluminum

Nasal ulcers, perforation of the nasal septumX metalsImmune System:Increased incidences of asthma, autoimmune-like symptoms, & allergies
X metals

Inhibition of lymphocytes, T-cells, monocytes X metals
Immunosuppression

LeadDecreased white blood cell count
Arsenic, ThalliumReproductive System:Genital abnormalitiesAluminum, ThalliumDisturbances in menstrual cycle; menstrual painsCopper, MercuryBirth defects; premature births; Spontaneous abortionArsenic, Lead, MercuryReproductive dysfunctionArsenic, AluminumOther Physical Disturbances:Hypotonia or hypertonia; decreased muscular strengthX metalRashes, contact dermatitis; eczema, itchy/irritating skinAluminum, Arsenic, Copper, MercuryMuscle pain; headache; acrodynia; colicArsenic, Copper, Lead, ThalliumAlopecia (hair loss)Thallium Reference: Published in the August issue of Alternative & Complimentary Therapies (a magazine for doctors) and Published in Townsend Letter for Doctor's and Patients.

Detoxamin Usage Instructions: Detoxamin EDTA Suppositories are solid, bullet-shaped preparations designed for easy insertion into the anus (back passage). Detoxamin is manufactured in a cocoa-butter base, a time-release agent (fatty acid base), and 750 mg of Calcium-Disodium EDTA. Detoxamin will dissolve at body temperature and will gradually spread over the lining of the lower bowel (rectum), where it is absorbed into the bloodstream. Detoxamin is designed to release 750 mg Calcium Disodium EDTA slowly, over an 80-minute period.

A. Detoxamin Protocol for More Severe Cases:
1. Take one suppository at night, prior to bedtime.
2. Take every night for up to 90 days. This will provide the medical equivalence of 30 IV Chelation treatments.
3. Take proper mineral/trace mineral/vitamin replacement every day.
4. Take all other suplementaion every day.B. Detoxamin Protocol for Less Severe Cases/Anti-Aging/Prevention:
1. Take Detoxamin every OTHER night, prior to bedtime.
2. Take Detoxamin every other night for 180 days (90 suppositories). This will provide the medical equivalence of 30 IV chelation treatments.
3. Take proper mineral/trace mineral/vitamin replacement every day.
4. Take all other supplementation every day.

Detoxamin Protocol AFTER A or B is completed:
Your bones are toxic for life. Lead and other heavy metals are stored in the bones and get re-distributed into the bloodstream. Therefore, it is highly recommended to continue maintenance with Detoxamin, this provides the ultimate in Anti-aging benefits.

1. Take 5 Detoxamin suppositories over a 30-day period. This porvides medically equal to about 2 EDTA IV treatments.
2. Take porper mineral/trace mineral/vitamin replacement every day.

Note: Detoxamin is designed to be taken at night, however some patients and physicians prefer taking a suppository in the morning after evacuation. (Optional)

How to Use Detoxamin:
Insert Detoxamin suppositories at night, prior to bedtime.
Eat early in the evening, about 4 hours prior to bedtime. (Reduces any discomfort).
1. Go to the toilet and empty your bowels if necessary.
2. Wash your hands.
3. Remove the plastic wrapping from Detoxamin.
4. Either squat or lie on your side with one leg bent and the other staight.
5. Gently but firmly push the suppository into the rectum, FLAT end first until past the sphincter muscle. By inserting the flat end first opposed to the pointed end, the suppository will travel higher up in the rectum more easily. If necessarey moisten the suppository with a little water. Push it in far enough so it doesn't slip out.
6. Close your legs and sit or lay still for a few minutes.
7. Wash your hands again.
8. Try not to empty your bowels for at least 80 minutes.
9. It is optional to take Detoxamin in the morning, after evacuation.

STORAGE: Store Detoxamin in a cool dark place, but not in the fridge. If Detoxamin suppository gets warm it may melt, put the fridge for a few minutes, this will return the suppository to its original state so it may be inserted.
Shelf Life: 2 Years
More information’s: here Chelation

The Dosage and Aplication is very important in the ozone procedure

The dosage is everything!!! Theophrastus Bombastus von Hoheim (better known, as Paracelsus)

First, our Integrated Medical School is located in the same city which goes trough the news-, in Chiang Mai, but we have nothing to do with Mr. Satori ( same as "Dr." Suchada, which goes trough our student newsletters with a lot of complaints - she is a Thai female and claimed she is "natural doctor" educated from Canada, she doesn't saw at all Canada ( after a newsmagazine research), in reality- she works for the Faculty of Agriculture (has no medical, more less Ayurveda background - at all) when she nobody wants to tell who she is - so she has deep sense of privacy - and we are distancing us from all her actions and her advertisements. We have nothing to do with her. She is only focused on financial benefits.

Our priority is always safety and education of the patients and students. Our main intention is to educate and to protect, not to hurt. I'm aware of it, there are in Asia, especially in the Ayurveda section, here in Chiang Mai, which claim and advertise knowledge in that way ( and have no education at all) this is quiet danger -as the fellow example shows. They tourists know about this kind of treatments from Europe or north America, okay I will try it, but in the end of the day after they get aware of it - this is the scam.

We are get many complaints in that way, because we are teaching this here in Asia, and there is not yet a quality management. But it seems only if some people get killed, we are listen the news and questions the treatments. What is about the colon infections, fractures during the massage, heavy metal and full of fungus poisoned supplements?

Is this really the treatments? Or is this the missing education? I this there is no watch dog here in Asia? I'm aware in Europe and north America, since 10 years - we are talking about quality management, how we can control it, how we can improve it? I guess in Thailand so far, we don't have it, I couldn't read about in English newspapers. or I miss it.

We are getting tons of emails and everybody asking the same questions, how safe is ozone treatment?

It is very safe, when you don't make this non-sense, what Mr. Sartori made. Everyone understand when you inject a pure gas (any gas!) in a human vessel this is very dangerous and life threatening, but this is not what us the German studies proved - in the procedures guide. So don't associate so much Mr. Sartori with legal ozone applications, like here:

Wednesday July 12, 03:42 PM
Mixed views on radical oxygen treatment
Many terminally-ill patients have turned to radical alternative oxygen treatment in a last ditch attempt to prolong, or even save, their lives.
Ozone therapy is a German healing practice praised by dozens of natural health advocates worldwide for more than five decades.

But the controversial treatment has met with harsh criticism from medical specialists who claim there is no evidence it is effective.
Ozone is in the spotlight after police in Thailand charged Austrian national Hellfried Sartori with fraud and practicing medicine without a license in the northern city of Chiang Mai.
They allege he injected foreigners with dangerous chemicals, and that he has already been convicted and jailed in the United States for illegally administering his so-called "ozone treatments".

But Sartori insists the injections are not linked to the deaths of some of his patients, many of whom hoped it might save them from cancer.
One Australian cancer patient, Kathleen Preston, sought a cure from the so-called Dr Ozone but died in hospital last July following the treatment.
Websites supporting ozone therapy claim oxygen can be used to treat and often cure hundreds of conditions, including cancer and HIV/AIDS.
The practice is legal in 16 countries excluding Australia. Several states in the US have passed legislation to ensure that such alternative therapies are available to consumers.
It is most commonly administered through intravenous injection, in water or as a low-pressure gas fed through the ear or rectum.
Oxygenation therapists believe that disease is caused by the absence of oxygen and loss of cellular ability to use oxygen for "good energy" metabolism, detoxification, and immune system function.
The therapy therefore restores the body's ability to produce "good" energy, "detoxify" metabolic poisons, and to kill invading organisms, they claim.
Several organizations and companies worldwide have dedicated themselves to promoting the practice, which a 1980 German study found to be safe and effective with few side effects.
But the medical community says there is no evidence the therapy works.
At the heart of the criticism is that ingestion, infusion, or injection of oxygen or hydrogen peroxide cannot re-oxygenate the tissues of the body as claimed.
Yahoo news

The are many things are unknown here in Asia, and the USA as well (maybe in Australia too). I met only few doctors they understand what ozone / oxygen does, but for sure there is a relationship, between cancer, blood and a lack of oxygen, but for sure the solution is not - to put liquid or as a gas pure ozone in any vessel in the human body. This is non-sense - and I'm not sure Mr. Satori - didn't know this. If you read more in detail the news, I'm not sure they patients really died from the ozone applications (or the high dosage of potassium? Why this?).

There is really not so much details in the news. But who come in the bad news is ozone/ oxygen treatments, and they have nothing to do with news.

What is happen here, Mr. Satori, hungry for money, claims some non-sense procedure, the people understand, he promise - he can treat cancer in a short time, that’s why he asking for his short time effort for US$ 50.000 (in 1! week). I don't understand anyone who can pay this for 1 week, but I guess the are in a last hope - and he abuse a treatment, which are helped many people - not in one week, not in his way - but in a safe way - which can improve so many things: the blood, the live quality, and on and on. In this case, we are recommend again, please educate your self, before you make any treatment. Please consult at least 3 doctors to get your own opinion, and don't believe and pay a fake illusion and promise.

For that reason our website shows many different sites to help you, to educate your opinion.

Can chelation destroy the AIDS virus?

Archives of Virology 73, 171-183 (1982)
Disintegration of Retroviruses by Chelating Agents

By V. Wunderlich and G. SydowCentral Institute for Cancer Research, Robert-Rossle-Institute,Academy of Sciences of the German Democratic, Berlin

German Democratic RepublicWith 2 figures Accepted April 2, 1982
Summary

Exposure in vitro of various mammalian retroviruses to the chelating agents EDTA or EGTA in millimolar concentrations resulted in partial disintegration of viral membranes as measured by accessibility or even release of reverse transcriptase, an internal viral protein, without any other treatment usually required.

AMong the viruses responding to chelators were mammalian type C viruses, primate type D viruses and Bovine leukemia virus. The effect was dose-dependant. The avain type C virus AMV, howeveer, was found to be not susceptible to the agents. Rauscher mouse leukemia virus treated in vitro with EDTA or EGTA showed reducedinfectivity in mice.

The results are considered as evidence for some association of divalent cations with membranes of mammalian retroviruses. The disintegrating activity of EGTA suggests that Ca2+ is an integral constituent of viruses but Mg2+ may also be involved.

These cations seem to be responsible for maintaining the integrity of retroviral membranes which, after chelation of ions, are either disrupted or become permeable for the exogenous template of reverse transcriptase. In addition, the disintegrating activity of trifluoperazine may indicate that a calmodulin-like protein occurs in retroviral membranes.

Introduction
Retroviruses contain a single stranded RNA genome and the enzyme reverse transcriptase (RT), both of which are located with the virion core. Viral particles are released by budding from the surface of infected cells and the cores are thought to acquire in this process an outer unit membrane of host cell origin.

However, little is known about the composition, architecture and topography of the viral membrane witht he possible exception of spikes and knobs protruding from the exterior of the envelope. The porphological elements are composed of predominantly glycosylated proteins encoded in the viral genome and determine many of the biological properties of the virus. (see 23 for a review). Therefore, previous investigations on the retroviral envelope have mainly been focused on those components.

The demonstration of RT activity requires the disruption of virus particles as usually performed with the aid of detergents. Our observation that the preparation of type D retroviruses in buffers containing the chelating agent ethylene-diaminetetraacetic acid (EDTA) results in considerable accessibility or even release of RT activity without the use of any detergent (32) led us to investigate more systematically the action of chelating agents on different types of retroviruses.

The results presented in this study demonstrate that susceptibility to such agents is a characteristic property of various retroviruses. Thus, the structure of retroviral membranes obviously stabilized by divalent cations may be more complex than hitherto known. Appreciation of this complexity may allow a better understanding of certain aspects of virus-cell interaction and may facilitate the future design of antiretroviral compounds.

Materials and Methods
Chemicals
EDTA (Chelaplex III, p.a.) was purchased from VEB Berlin-Chemie, Berlin-Adlershof, GDR. EGTA [ethylene glycol bis 92-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Dr. Th. Schuchardt GmbH., Munchen, FRG) was kindly provided by Dr. H. Will, Berlin. Propranol was obtained from Isis-Chemie KG< la=" 1-"> Chelation and EGTA obviously disassociated some membrane components as indicated by the appearance of RT activity in otherwise undestructed virus samples.

This effect however, was sometimes hard to reproduce possible owing to some irreversible chelator induced activation of RT, a zinc metallozyme not reactivable by Mg++ or Mn++ (25), even although either ion was additionally added to the RT reaction mixture in amounts equimolar to the chelator. (Tables not included here but an be faxed to you if you are interested in seeing them.)

Efficacy of EDTA and EGTA in Disintegrating Various Retroviruses To circumvent the problems just described, most experiments were performed in a fashion allowing a more favorable ratio of chelator to virus during exposure as well as the subsequent elimination of major amounts of chelating agents before assaying for RT activity, i.e., sedimentation of viruses through a solution containing the agent under study. Results are expressed as lytic activity LA as defined in Materials and Methods.

This index reflects the ability of a given agent to bring about a partial or complete disintegration of virus particles. Partially disintegrated particles, although to a variable extent damaged by exposure to chelator, remain sedimentable but exhibit RT activity as seein in aliquots (c) treated with agent but not with detergent.

On the other hand, the proportion of virus particles completely disassembled during exposure may be obtained by the difference of RT activities appearing in aliquots (b) and (d) treated without or with agent followed by disruption of the remaining virus with detergent.

To give an example with RLV exposed in aliquots (c) and (d) to 1 mmol/l ETA: the four viral aliquots displayed RT activities of (a) 1.1, (b) 38.0, (c) 10.4, (d) 32.7 dis/min (each x 10 to the third), respectively, yielding an LA value of 40. It appeared, however, not meaningful to discriminate between partial and complete disintegration and the LA value included by definition both events was therefore used. Fig. 1 (not shown) depicts the action of EDTA and EGTA on various retroviruses. These include mammalian type C viruses (RLV, SSV), primate type D viruses (MPMV, SMRV, PMFV) and BLV. Both chelating agents exert in millimolar concentrations a pronounced lytic activity upon most of the viruses tested so far.

Mammalian type C viruses seem to be somewhat less susceptible than the other viruses. The avian type C virus AMV, however, was exceptional in that it did respond to neither EDTA or EGTA. The reason for that was not investigated but may be related to some peculiarities of the envelopes of the avian type C viruses as compared to their mammalian counterparts (23). Since RLV just as AMV was obtained from the plasma of leukemic animals and there was no difference in the susceptibility of RLV irrespective of originating from infected animals or tissue cultures, it appears to be unlikely that unresponsiveness of AMV is due to certain conditions of extracellular viral maturation.

Concentration Dependence of Disintegrating Activity of EDTA and EGTA In initial experiments it was noted that retroviruses respond to chelating agents in a dose dependant manner. Fig. 2 (not shown) illustrates that PMFV, studied in greater detail, is susceptible to chelators over a wide range of concentrations. Complete disintegration, however, was reached with neither EDTA nor EGTA even in high concentrations up to 50 mmol/l.

This may indicate that only a certain fraction of particles present in a given virus population is sensitive to these agent possible owing to variations in age, stage of maturity, or other factors. Such variables are known to influence the response of retroviruses to detergents (43). Which Ion Is Involved in Disintegration A major question arising from the experiments described so far is the nature of the cation complexed by the chelating agents and probably somehow responsible for the integrity of viral particles. Effectiveness of EGTA with its high binding affinity for Ca++ (stability constant log K=10.9) and relatively low affinity for Mg++ (log K=5.9) (3) clearly supports a role of calcium in virus integrity.

However, the ability of EGTA to produce disintegration even in low concentrations may suggest that magnesium is also involved in maintaining the integrity of retroviruses, since the EDTA has binding affinities to both Ca++ (log K = 10.7) and Mg++ (log K = 8.9). The low amount of virus available for analysis did not yet allow an identification of the respective cation(s) by means of chemical or physicochemical methods. The possibility that EDTA and EGTA chelate different cations in retroviral membranes led us to examine a possible synergistic action of both agents on retroviruses.

Thus far, however, no increase in LA values has been observed after exposure of viruses to equimolar mixtures of both chelators. To further substantiate the involvement of one of the ions under consideration, experiments were performed to ascertain whether the addition of divalent cations could prevent the action of EDTA or EGTA (not shown). As already reported for PMFV (32) and now confirmed with other viruses, both MgCl2 and CaCl2 prevented disintegration of retroviruses when simultaneously added with the chelating agent.

However, addition of these cations at a later time did not cancel the effect produced by EDTA or EGTA. These results corroborate the assumption that both Ca++ and Mg++ ions are associated with retroviruses. Moreover, they exclude the possibility of involvement of such heavy metal ions binding more strongly to EGTA than Ca++, because in that case addition of CaCL2 or MgCl2 would not have prevented disintegration.

Effect of EDTA and EGTA on Infectivity of RLV That chelating agents indeed adversely affect retroviral membranes was independently demonstrated in another set of experiments. RLV, contained in cell-free spleen homogenates, was incubated in vitro with EDTA or EGTA and then injected into mice for analysis of leukemogenic capacity.

As compared to saline incubated virus in the controls, this treatment led to a marked inhibition of splenomegaly as well as to a doubling of mean survival time of infected animals (Table 2 not shown). Therefore, disintegration of virus particles as biochemically measured is paralleled by an equivalent loss of infectivity. The remaining virus, however, was still able to cause leukemia being diagnosed (courtesy of Prof. F. Fey) at the time of death of animals. Nevertheless, antiviral activity of chelating agents was also reflected in the pronounced depression of particle bound RT activity in the plasma of mice inoculated with treated virus.

During the course of development of leukemias, there was a considerable delay in reaching comparable levels of RT activity in blood of treated as against control mice. Susceptibility of BLV to Different Beta Blockers The hypothesis that Ca++ may be associated with retroviruses was further tested in animals with beta receptor blocking drugs.

Propranolol, a nonselective beta blocker used in medical practice, has been shown to be able to interact with membranes under concomitant Ca++ displacemant (2). It also disrupts membranes of type C and type D retroviruses (41). Contrary to propranolol, some of its congeners cardioselective beta blockers like practolol, sotalol and atenolol lacking the hydrophobicity of propranolol, do not essentially influence membrane phospholipids and membrane boud Ca++ (2,17,24).

For that reason it appeared of interest to examine the susceptibility of a retroviruses to these drugs. BLV was chosen because it was not included in our earlier studies. Table 3 (not shown) shows that exposure to propranolol in vitro clearly disintegrates BLV, as previously demonstrated with other retroviruses. Exposure to one of the propranolol congeners however produces only a small, if any, disintegration of BLV.

These results may thus provide additional evidence for calcium as the ion to take into consideration. Lytic Action of Trifluoperazine on Retroviruses The effect of trifluoperazine (TFP) on retroviruses ws investigated because

(i) other phenothiazines have been found to exert a lytic effect on retroviruses in vitro (41),

(ii) drugs of this type are known to produce, along with a variety of other effects on biological membranes, a displacement of Ca++ from membrane components (29) and

(iii) TFP is able to bind in a Ca++ dependant manner (18,19) highly effectively to calmodulin, a widespread regulatory protein (16), and is therefore widely considered as a specific probe for calmodulin. In view of these properties disintegrating activity of TFP on retroviruses could serve as an indicator both for the presence of Ca++ and for the identification of a putative Ca++ binding molecule in retroviral membranes. In fact, following exposure to TFP retroviruses of type C or type D as well as BLV displayed a release of RTactivity (table 4) [not shown].

The effect was again dose dependant. To favor a Ca++ specific binding of TFP to viral components, exposure was performed at pH 7.2 and not at pH 8.3 as usually, because pH values above 7.5 diminish the specificity of binding (36) .

Despite some variations with different viruses, TFP showed a similar disintegrating activity as various phenothiazines (41). Although AMV failed to respond to EDTA and EGTA, this virus was found to be susceptible to TFP, similarly as to other phenothiazines (41), too. From the results of this set of experiments it is tempting to conclude that retroviral membranes donot only contain Ca++ but possible also a Ca++ binding protein (7) which may be calmodulin like in sharing with this protein the property of responding to TFP.

Discussion In the present work designed to evaluate the action of the action of chelation agents on retroviruses in vitro we have mainly used a procedure sonsisting of centrifugation of intact virus particles through a solution of each respective agent and subsequent assay for RT to detect disintegration of the viral membrane.

The results show that these agents are capable of disintegrating all of the mammalian retroviruses tested. This finding was supported by experiments showing decreased infectivity of RLV after the virus had been treated with chelating agents. Principally, disintegration of retroviruses in vitro may occur either spontaneously or by treatment with membrane active agents. Spontaneous disintegration thought to be due simply to aging of particles is variable but usually low.

On the other hand, a variety of agents including detergents (21) , lipid solvents (21), and neurotropic drugs (41) as well as proteins such as human (37) or nonhuman primate complement (30) and melittin (12) cause a complete or nearly complete lysis of retroviruses. Complement mediated virolysis affects the P15(E) protein known to be embedded directly into the retroviral membrane (1).

Other interesting agents are the polyene antibiotics and membrane channel formers filipin (22) and nystatin (12) which induce some alterations in but nor disintegration of the membranes of retroviruses while retaining their infectivity.

This study revealed still another type of response with some dissociaton of membrane components that affects the infectivity of virus but does not necessarily result in complete destruction of viral particles because a variable proportion of them remains sedimentable even after treatment with chelators. Thus, retroviruses may exhibit a broad range of response to exogenous factors. However, among such factors, chelators like EGTA are rather exceptional in that they do not represent true membrane active agents, although several observations point to a role of Ca++ in membrane stability. (6).

There is increasing evidence for some association of Ca++ with viruses and a role of this ion in maintaining viral structure. The observation of calcium binding sites is nearly 20 plant viruses including tobacco mosaic virus, and also bioenergetic considerations, led DURHAM (10,11) to propose that Ca++ might generally control disassembly of such viruses. Other authors succeeded in disassociated of polyoma virus by chelation of Ca++ (4) and reassembly of infectious viral particles by subsequent addition of Ca++ (5). Exposure of rotavirus particles to calcium chelators resulted in an unmasking of internal RNA polymerase activity (9).

On the basis of these findings it is tempting to assume that association with Ca++ is a widespread property among viruses of different families. The viral components associated with Ca++ have not been identified. One possibility is that the attachment of Ca++ to phosphatidylserine (13) known to occur in the so far analyzed retroviral membranes (28). Distinctive features of model membranes have been attributed to interactions of Ca++ with membrane phospholipids and there is evidence that the viral membranes behave in this respect similarly as model membranes, e.g., in virus induced cell fusion processes (27). On the other hand, certain proteins could serve as receptors for Ca++ owing to their ability to bind Ca++ in a selective and reversible fashion.

The prototype of such Ca++ binding proteins is calmodulin, which, upon binding of Ca++, undergoes a confirmational change needed for its biological activity (16). In the presence of Ca++, calmodulin avidly binds phenothiazines (with TFP being the most effective one) and becomes thereafter biologically inactive (36). Propranolol is another antagonist of calmodulin (35).

Consequently the strong retrovirus disintegrating activity of TFP, other phenothiazines, and propranolol (41) may be considered as preliminary evidence for the occurrence of calmodulin like proteins in retroviral membranes, though it remains to be identified. During complex formation of Ca++ both with phospholipids (26) and proteins (39) there is some synergism with Mg++ and it is, therefore, well conceivable that both cations simultaneously occur in rteroviral membranes.

Whatever the mode of Ca++ binding to viral components is, and irrespective of whether Ca++ is accidentally or even specifically complexed to them, the occurance of Ca++ in retroviral membranes may have biological implication with regard to the assembly and disassemble of viral particles in and their budding from infected cells. Generally Ca++ has been found to influence a wide variety of functional properties of biological membranes.

Finally, identification of Ca++ binding viral components may eventually prove useful in the search for new and effective retroviral agents. The presently limited success of virus chemotherapy with chelating agents (20) might be generally augmented by considering such components as drug targets, too. Our recent demonstration that haloperidol, a colmodulin binding butyrophenone (19), exerts an antiviral effect on Raucher murine leukemia virus in vivo (42), may support the feasibility of this approach.

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Bio-Chelat: Chelation Therapy Clinical Trial - US Study

Clinical Investigation of Bio-Chelat(TM) Chelation Therapy

Results of the Bio-Chelat(TM) Clinical Study with Doctors Data Inc.

The clinical study was conducted over a 14 day-period, starting January 6, 2002 and ending April 18, 2002. Only 11 of the 20 participants fully complied with the experimental protocol and completed the Bio-Chelat(TM) clinical study.

Due to the limited number of observations, David Quig Ph.D. of Doctors Data, was unable to perform the appropriate statistical analysis required for a legitimate evaluation of the trial results. The German Bio-Chelat(TM) study utilized blood, while the U.S. study made use of urine and fecal analysis.

In retrospect, and on close review of all data, Target Your Health, Inc. noticeably sees, that the test design was not fully appropriate because of the specific pharmacokinetics of Bio-Chelat(TM). The decision was therefore made to revise the experimental design study, monitor patient compliance more closely, and conduct another clinical trial utilizing blood in conjunction with Doctors Data.

Nevertheless Dr. David Quig of Doctors Data stated: "Although the U.S. study sample was insufficient, it appears that the preliminary data that was collected show that Bio-Chelat(TM), chelation therapy, brought about elimination of heavy metals of the participants."
To understand how the Bio-Chelat(TM) solution differs and works in comparison to other chelators i.e. (DMPS, DMSA,EDTA, etc), following is a summary description of the pharmacokinetics.

Clinic-Pharmacological Data of Bio-Chelat(TM).
Pharmacokinetics: Bio-Chelat(TM) contains a complex-forming agent (EDTA) and an oxidative catalyst. The oxidative catalyst has the following function:1. To oxidize the SH-groups into SO3 2- groups or SH-ions into sulfate. SH-groups or SH-ions are ubiquitous in the GI tract and form very strong bonds with heavy metals.

The bonds of the newly formed SO32-groups or sulfate groups are reduced, thus allowing this very low concentrated (homeopathic) dosage of EDTA to easily bind with the heavy metal ions. In an acidic environment (i.e. stomach, intestines etc), EDTA forms a high complex bond with mercury, cadmium and lead. Because of this, heavy metals coming from the food, teeth roots, bile etc. are chelated and excreted with the feces.

By decreasing the uptake of mercury ions into the blood stream and creating a high electric-magnetic gradient in the GI-tract, new heavy metal ions are pulled from the body into the blood stream and stomach/intestine and excreted (Law of Isotonicity).

One example: When taking Bio-Chelat(TM), (DL) the urine clearly showed an increased amount of Cadmium and Nickel. On the other hand, fecal excretion of Cadmium, Mercury, Lead decreased.Analysis: When Bio-Chelat(TM) is absorbed into the GI tract, heavy metals are chelated and excreted with the feces.

This "clean-up" of the GI tract can last between 24 hours to 1 week and depends on the patient. During this period higher values of excreted heavy metals can be seen. Once the "clean-up" is completed, a lower concentration of heavy metals is then found in the feces. Lesser heavy metals are now absorbed into the blood, creating an imbalance between the blood and the deposits, which then will pull new heavy metals into the blood stream from the deposits, which are then excreted via the urine and feces.

As formulated by Dr. Leman in the German study:
Bio-Chelat((TM), chelation therapy, will indirectly intensify the body's physiologic elimination mechanism of heavy metals. When comparing values prior to Bio-Chelat(TM) intake, due to the minimization of heavy metals into the blood (blood doesn't receive anymore metals from the GI-tract), the balance between heavy metal depots and blood is disturbed, and heavy metals spill over (are pulled) into the blood, and are then discarded via the kidneys and intestines.

An increase in the heavy metal concentration of the urine and feces should not be measurable, because even the blood level of heavy metals should now be inferior compared to the pre-therapeutic level. For long-term therapy, this physiological mechanism can be utilized to eliminate heavy metals.

Final Conclusion
The therapeutic value of Bio-Chelat(TM) in the context of chelators currently on the market is seen as follows:

a) Chelators work relatively fast, but they are also very strong with a relative high washout of important trace elements and a high degree of specific side effects.

b) Bio-Chelat(TM), chelation therapy, works much gentler and is easier as most common chelators.

c) Bio-Chelat(TM) is not suitable for acute care of heavy metal toxicity or a very high toxic ion loads.

d) Bio-Chelat(TM) has its greatest value as a middle and long-term therapy for chronic heavy metal toxicity and especially in preventing heavy metal toxicity through the today's overall heavy metal exposition. For this it is the optimal product.

e) The side effects of Bio-Chelat(TM) are minimal when compared to the overall effect. Those side effects can be totally eliminated through a modification of intake and dose. No associated risks are connected with the use of Bio-Chelat(TM).
Because of this, Bio-Chelat(TM), chelation therapy, is excellent in view of the numerous patients carrying a chronic heavy metal ion load.
It is a necessary solution.

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http://www.dreddyclinic.com/integrated_med/chelation.htm