An Oculocerebrovasculometric Analysis of the improvement in Arterial Stenosis following EDTA Chelation TherapyE.W. McDonagh, DO, FACGPC.J. Rudolph, DO, PhDE. Cheraskin, MD, DMD
ABSTRACT: Fifty-seven patients were evaluated objectively for cerebral vascular arterial occlusion before and after an average of 28 intravenous infusions of disodium ethylene diamine tetraacetic acid. Measurements of arterial occlusion were made with the relatively simple, noninvasive oculocerebrovasculometric analysis.
Cerebrovascular arterial occlusion diminished by an average of 18% (from a mean of 28% to a mean of 10%) following therapy (P<0.001). href="http://www.dreddyclinic.com/integrated_med/chelation.htm">EDTA chelation therapy showed objective improvements in cerebrovascular blood flow.
Since C. Miller spelled out the clinical syndrome of carotid occlusive disease in 1951,
1 there have been increasing efforts to develop non-invasive tests for diagnosis of common and internal carotid lesions. The plethora of diagnostic procedures testifies to the difficulty in arriving at a fully satisfactory single technique.
2 This report, as far as we can ascertain, is the first attempt to examine the effect of intravenous disodium ethylene tetraacetic acid (EDTA) therapy plus multivitamin-trace mineral support upon arterial insufficiency (stenosis) utilizing one of the popular non-invasive techniques, namely oculocerebrovasculometry (OCVM).
Fifty-seven routine patients suffering with chronic degenerative disorders participated in this experiment in a private practice environment. Included were 34 males, age range from 23 to 83 years old with a mean and S.D. of 61.4 ± 11.2; and 23 females from 48 to 77 years old with a mean and S.D. of 60.2 ± 7.8.
At the initial examination, each patient underwent a detailed history, physical examination and comprehensive battery of biochemical tests. Each patient also underwent oculocerebrovasculometry (OCVM), a unique non-invasive tonometric system for the detection of arterial insufficiency (stenosis).
This technique was developed in cooperation with Maurice Langham, Ph.D., of the Wilmer Institute at Johns Hopkins University School of Medicine, 3,4 This non-invasive system simultaneously measures intraocular pressure and ocular pulse in both the undisturbed state and with the eye pressure increased to the ophthalmic arterial pressure.
The procedure measures the ophthalmic arterial pressure which, when compared to the brachial blood pressure, provides a reasonably accurate method of assessing carotid artery occlusive disease, cerebrovascular occlusive disorders, and ocular vascular pathology.5 Following the initial studies, each subject received a series of intravenous disodium EDTA infusion with a mean and S.D. of 28.4 ± 7.7 (ranging from 10 to 46).
Additionally, a multivitamin-trace mineral supplement (dosage approximately five to 10 times the RDA) was supplied. Upon completion of the EDTA and multivitamin-trace mineral series, each individual once again received a comprehensive history, physical examination, battery of biochemical tests, and oculocerebrovasculometry.
Five points deserve particular consideration. First, at the beginning, the mean percentage of arterial stenosis was 28% with a range from 3% to 74%. Following therapy, the average stenosis was 10% with a range from 0 to 54%. Hence, there was an overall statistically significant reduction in arterial occlusion of 18% (t=7.1931, P<0.001).>
Third, following treatment, at every temporal point, there is a significant mean reduction in stenosis of an order of 18% (t=5.3516, P<0.001), t="5.2566," t="1.6147,">
REFERENCES 1. Fisher M: Occlusion of the internal carotid artery. Arch Neurol Psychiatr 1951;65:346-377. 2. Ackerman RH: Cerebrovascular Survey Report. Non-invasive diagnosis of carotid disease. Washington, Joint Council Subcommittee on Cerebrovascular Disease. National Institute of Neurological and Communicative Disorders and Stroke and National Heart and Lung Institute. 1980 pp. 190-210. 3. Langham ME: A new procedure for the analysis of intraocular dynamics in human subjects. Exp Eye Res 1963;2:314-324. 4. Langham ME, To'mey KF: A clinical procedure for the measurement of the ocular pulse-pressure relationship and the ophthalmic arterial pressure. Exp Eye Res 1978;27:17-25. 5. To'mey KF, Langham ME: in press.
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