Monday, August 07, 2006

How Transfer Factors Are Prepared

Transfer factors (TFs) act as immunomodulators, and recent research suggest that TFs May work directly at the level of DNA polymerization processes, creating larger mole-Cules from smaller ones. The TFs them selves are tiny protein molecules known as oligoribonucleotide peptides, that are one seventh to one-fiftieth the size of antibodies. TFs are derived either from colostrum or from filtered leukocytes and lymphocytes from the blood.

Chisolm Biological Laboratory, (CBL), a leader in the manufacture of TFs, uses purified dialyzable leukocyte txtracts (DLE-TFs) derived from the white blood cells of chickens. "Dialyzable" means that the white blood cell protein materials have passed through dialysis filtration and Are extremely small, which ensures that there is no risk of infection in human recipients with animal host antigens.

Each batch of CBL TF is prepared through a series of processes. First, the host blood cells are removed, Then white blood cells (WBCs) are separated out by a mechanical centrifugation technique. Next, the WBCs are broken apart by freeze-thawing and sound waves (sonication), after which the broken-up cells are sent through dialysis fil­tration to yield a low molecular weight extract that is then further fractionated and purified.

A sample of the TF extract is first tested for sterility and absence of toxins, then for potency. This TF sample is then introduced into yet another large production group, and the process is repeated. The extract material, produced by passing TF extract through several purification stages, ensures the greatest safety and efficacy of the final product. To date, no adverse side effects have been reported from the use of TF, even when TFs are administered in extremely high dosages or consecutively over several years.

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