Amazingly, grapefruit juice can interfere with some prescription medications. Grapefruit and its juice contains a phytochemical that inhibits the enzyme needed to break down antihistamines, calcium-channel blockers, immunosuppressants, sedatives and protease inhibitors (treatments for Aids), among others. As a result, blood levels of those drugs stay higher than expected, with potentially serious side effects. If you drink grapefruit juice regularly and are prescribed medication, mention it to your health care provider.
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